Stat1 and cancer
WebMar 1, 2024 · JAK‐STAT core cancer pathway: An integrative cancer interactome analysis - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. sharing sensitive information, make sure you’re on a federal WebMay 13, 2024 · The signal transducer and activator of transcription (STAT) family of proteins serve an important role in the initiation of malignant transformation and in tumor establishment, and have been widely studied in experimental …
Stat1 and cancer
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WebJan 1, 2024 · STAT1 constitutively interacts with the MUC1-C subunit in breast cancer cells which results in an up-regulation of STAT1 target genes and MUC1 itself. The … WebWe, the Editors and Publisher of the journal Cell Cycle, have retracted the following article:. Yuguang Yang, Jin Wu, Hongfeng Zhou, Wenming Liu, Jincai Wang and Qingyuan Zhang. STAT1-induced upregulation of lncRNA LINC01123 predicts poor prognosis and promotes the progression of endometrial cancer through miR-516b/KIF4A.
WebThe treatment of ADAR1-depleted AGS cells with an miR-302a mimic successfully restored IRF9 as well as STAT1 protein level. Hence, our results suggest that ADAR1 regulates IFN … WebMar 23, 2024 · Existing evidence reveals that STAT1 has both tumor-suppressing and tumor-promoting functions involved in angiogenesis, cell proliferation, migration, invasion, …
WebThe cross-talk between STAT1 and STAT3 in cancer has not been fully demonstrated. Materials and methods: Esophageal squamous cell carcinoma (ESCC) was used as a … WebMay 8, 2024 · The tumor-suppressive role of STAT1 is driven by findings that the reconstitution of STAT1 in STAT1-deficient murine fibrosarcoma cells significantly suppressed tumorigenicity and metastasis in nude mice. 53 The high expression of STAT1 is reported to have a good prognosis compared with the low or negative expression of …
WebSTAT1 is required for signaling of all the interferons (α, β, γ, ω, λ). Complete (recessive) loss of activity of STAT1 leads to early fatal infections with mycobacteria and viruses. …
WebOct 31, 2016 · Altogether, these data indicate that IL-27 and IFN-γ display a broad overlap of functions in human cancer cells, which are related to STAT1 pathway activation by both cytokines. Therefore, the effects of STAT1 seem to prevail over those of STAT3 signaling, which is also activated by IL-27 and may be involved in the regulation of a smaller set ... good engineering colleges in ohioWebAug 1, 2024 · The first STAT family member, STAT1, is an essential component of interferon (IFN)-signaling, which mediates several cellular functions in response to stimulation by cytokines, growth factors, and hormones, such as the IFNs and IL-6. The role and significance of STAT1 in cancer biology have been studied for a decade. good engineering colleges in floridahealth recordWebNov 29, 2024 · Background: Signal transducer and activator of transcription (STAT) 1 is an important transcription factor and has been reported to be a tumor suppressor in many types of cancer. However, another STAT family member, STAT3, is considered to be an oncogene. The cross-talk between STAT1 and STAT3 in cancer has not been fully … good engineering practiceWebSTAT1 exerts a complex array of functions on both tumor cells and the immune system and is usually considered as a tumor suppressor.12In contrast, STAT3 is considered as an oncogene and its constitutive … health record and information technologyWebSep 24, 2024 · As a point of convergence for numerous oncogenic signaling pathways, signal transducer and activator of transcription 3 (STAT3) is central in regulating the anti … good engineering colleges in maharashtraWebThe treatment of ADAR1-depleted AGS cells with an miR-302a mimic successfully restored IRF9 as well as STAT1 protein level. Hence, our results suggest that ADAR1 regulates IFN signaling in gastric cancer through the suppression of STAT1 and IRF9 via miR-302a, which is independent from the RNA editing of known IFN production pathway. good engineering colleges in hyderabad