Web10 sep. 2024 · The discovery that androgens play an important role in the progression of prostate cancer (PCa) has led to the development of androgen deprivation therapy as a first line of treatment against PCa. However, paradoxical growth inhibition has been observed, both experimentally and clinically, in a subset of PCa upon administration of … Web3 dec. 2024 · However, little is known about the role of nucleophagy in LSEC defenestration. Herein, we aim to dissect the underlying mechanism of progerin and nucleophagy in LSEC phenotype. We found an abnormal accumulation of progerin and a loss of SIRT1 in the nucleus of intrahepatic cells in human fibrotic liver tissue.
IJMS Free Full-Text Autophagy Modulators in Cancer Therapy
WebΟ Νεκτάριος Ν. Ταβερναράκης (γενν. 2 Μαΐου 1967) είναι Έλληνας βιολόγος και πανεπιστημιακός, με καταγωγή από το Ηράκλειο Κρήτης. Είναι Καθηγητής της Ιατρικής … WebNucleophagy, the selective subtype of autophagy that predominantly targets only a selected and (nonessential) portion of the nucleus, and rarely the nucleus in its entirety, … bubble 07 toms river
Nucleophagy mediators and mechanisms - PubMed
Web30 jan. 2012 · Autophagosomes are double-membrane vesicles characteristic of macroautophagy, a degradative pathway for cytoplasmic material and organelles terminating in the lysosomal or vacuole compartment for mammals and yeast, respectively. This highly dynamic, multi-step process requires significant membrane reorganization events at … Web1 jul. 2016 · Thus, nucleophagy in keratinocytes is a targeted process whereby nuclear material within the nucleophagic regions differs from that within the intact nucleus where … Web3 dec. 2024 · Some of the nuclear alterations also contain autophagic proteins and Type II DNA Topoisomerases (TOP2A and TOP2B), or nucleolar protein Fibrillarin, implying they … bubb landshut