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Maccannell fibroblast model

WebSimulations of F-M coupling pairs comparing coupling via dynamic Cx43, Cx45, and Cx43/Cx45 GJs to a static model. (a) Dynamic GJ models were used to couple the MacCannell fibroblast model to the modified Livshitz and Rudy model [] and compared it to the static model and an uncoupled cardiomyocyte model.From top to bottom: … WebNov 11, 2014 · The Ramirez-Nattel-Courtemanche (RNC) ionic model of canine atrial cardiomyocyte action potentials (APs) ( 25) was implemented and electrically connected to a variable number ( n) of MacCannell model fibroblasts ( 20) via gap junctions of conductance G gap. The total ionic current for the RNC model (I ion,RNC) is

Computational modeling of cardiac fibroblasts and fibrosis

WebMacCannell et al. used computational models of cell pairs using the Tusscher-Noble-Noble-Panfilov (TNNP) model of the human ventricular cardiomyocyte and their active … WebIt consists of a highly detailed 3D geometric model of the atria (754,893 nodes and 515,005 hexahedral elements with a homogeneous resolution of 300 μm) coupled to a torso model (254,976 nodes and 1.5 M tetrahedral elements) made up of lungs, bones, liver, ventricles, blood, and general torso, see Figure 1A. mayflower health center https://obiram.com

Effect of myocyte-fibroblast coupling on the onset of …

WebMay 1, 2008 · The electrophysiological properties of the fibroblasts were described by the MacCannell et al. ( 34) fibroblast model. This membrane kinetics model incorporates a time-dependent K + current formulated using two gating variables, an inward-rectifying K + current, an Na + -K + pump current, and a background Na + current. WebThe computational modeling of the cardiac electrophysiology allows assertive and quantitative study of the atrial fibrosis under fibrillation conditions. The cardiac electrical propagation is... WebMar 1, 2014 · In this study, the effects of cardiac fibroblast proliferation on cardiac electric excitation conduction and mechanical contraction were investigated using a proposed integrated myocardial-fibroblastic electromechanical model. At the cellular level, models of the human ventricular myocyte and fibroblast were modified to incorporate a model of … hertha olympiastadion

Simulations of F-M coupling pairs comparing coupling via

Category:Mathematical modelling of the mechano-electric coupling …

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Maccannell fibroblast model

A Mathematical Model of Electrotonic Interactions between Ventricular ...

WebThe model is an extension of established cardiac bidomain models, which include a description of intra-myocyte and extracellular conductivities, currents and potentials in … WebIn the MacCannell model, four membrane ion currents are considered for fibroblasts: a time- and voltage-dependent “delayed-rectifier” K + current iKv, an inward-rectifying K + …

Maccannell fibroblast model

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WebJan 20, 2024 · MacCannell, K. A. et al. A mathematical model of electrotonic interactions between ventricular myocytes and fibroblasts. Biophysical Journal 92 (11), 4121–4132 … WebFeb 16, 2007 · First, fibroblasts were modeled as a spherical cell with a capacitance of 6.3 pF and an ohmic membrane resistance of 10.7 GΩ. When these “passive” fibroblasts …

WebIonic channel currents of the atrial fibroblast model. (A–C) The simulated I-V curves for the major ionic currents (solid lines) are shown along with the respective experimental data … WebJul 3, 2024 · Atrial fibrosis is characterized by expansion of extracellular matrix and increase in the number of fibroblasts which has been associated with the development and maintenance of atrial arrhythmias. However, the mechanisms how the fibrosis contributes to atrial arrhythmia remain incompletely understood. In this study, we used a proposed …

WebAug 23, 2016 · We patch-clamped guinea pig ventricular cardiomyocytes and used the dynamic-clamp technique to couple them to the MacCannell fibroblast electrophysiology model ( 27) via GJ channel models developed to represent the gating and kinetic properties of Cx43, Cx45, and Cx43/Cx45. WebDec 10, 2024 · Originating from the fibroblast model of MacCannell et al. (2007), the active model of Maleckar et al. (2009) includes the fibroblast membrane capacitance and four fibroblast ionic currents: time- and voltage-dependent fibroblast K + current (I KV), inward-rectifying K 1 + current (I K1) which is expressed in cardiac myofibroblasts, Na +-K ...

WebDec 15, 2011 · Human atrial tissue model with regionally proliferated fibroblasts. A, Schematic representation of the Courtemanche human atrial myocyte model 16 …

WebJan 1, 2024 · The MacCannell model utilized in our study includes two interacting compartments: a human cardiomyocyte model (TP06) and an adult fibroblast model. … hertha ossanaWebFibroblasts play a significant role in the development of electrical and mechanicaldysfunctionoftheheart;howevertheunderlying mechanismsareonlypartiallyunderstood.Onewidelystudied mechanism suggests that fibroblasts produce excess extracellular matrix, resulting in collagenous septa. her thaoWebThe fibroblast model16includes time- and voltage-dependent K current (I Kv ), inward-rectifying K current (I K1 ), Na -K pump current (I NaK ), and Na background current (I … hertha orglerWebical models of ventricular fibroblasts, a passive model (Xie et al., 2009b) and an active model (MacCannell et al., 2007), have been developed. However, to the best of our … mayflower heberWebThe active force of fibroblasts was therefore ignored at the cellular level in this study. 2.1.3 Tissue modeling With the above mentioned cellular electrome- chanical models for myocytes and fibroblasts, both AP and Tacan be computed and then incorporated into the following tissue models. mayflower hearingWeb(A) The MacCannell model predicts myocyte action potential duration and fibroblast potential elevation are shortened as the number of fibroblasts connected to myocytes is increased. Figure adapted with permission by Biophysical Journal from MacCannell et al. mayflower hemsworthhertha online