WebSimulations of F-M coupling pairs comparing coupling via dynamic Cx43, Cx45, and Cx43/Cx45 GJs to a static model. (a) Dynamic GJ models were used to couple the MacCannell fibroblast model to the modified Livshitz and Rudy model [] and compared it to the static model and an uncoupled cardiomyocyte model.From top to bottom: … WebNov 11, 2014 · The Ramirez-Nattel-Courtemanche (RNC) ionic model of canine atrial cardiomyocyte action potentials (APs) ( 25) was implemented and electrically connected to a variable number ( n) of MacCannell model fibroblasts ( 20) via gap junctions of conductance G gap. The total ionic current for the RNC model (I ion,RNC) is
Computational modeling of cardiac fibroblasts and fibrosis
WebMacCannell et al. used computational models of cell pairs using the Tusscher-Noble-Noble-Panfilov (TNNP) model of the human ventricular cardiomyocyte and their active … WebIt consists of a highly detailed 3D geometric model of the atria (754,893 nodes and 515,005 hexahedral elements with a homogeneous resolution of 300 μm) coupled to a torso model (254,976 nodes and 1.5 M tetrahedral elements) made up of lungs, bones, liver, ventricles, blood, and general torso, see Figure 1A. mayflower health center
Effect of myocyte-fibroblast coupling on the onset of …
WebMay 1, 2008 · The electrophysiological properties of the fibroblasts were described by the MacCannell et al. ( 34) fibroblast model. This membrane kinetics model incorporates a time-dependent K + current formulated using two gating variables, an inward-rectifying K + current, an Na + -K + pump current, and a background Na + current. WebThe computational modeling of the cardiac electrophysiology allows assertive and quantitative study of the atrial fibrosis under fibrillation conditions. The cardiac electrical propagation is... WebMar 1, 2014 · In this study, the effects of cardiac fibroblast proliferation on cardiac electric excitation conduction and mechanical contraction were investigated using a proposed integrated myocardial-fibroblastic electromechanical model. At the cellular level, models of the human ventricular myocyte and fibroblast were modified to incorporate a model of … hertha olympiastadion