WebMay 12, 2015 · As expected, the screen revealed that cancer cells that have mutations in the gene encoding p53 are insensitive to the anti-HDM2 drug because there is no … WebExpression Public 22Q4 Copy Number Public 22Q4 Hotspot Mutations Damaging Mutations Mutation Fusion Translocation Protein Array Methylation (1kb upstream TSS) Copy Number (Absolute) Proteomics. Compound Viability screens
NCIH2122 DepMap Cell Line Summary
WebNov 21, 2024 · H2122 cells were considered as AMG510-resistant cells with inhibitory rate less than 20%. The rest of the cell lines exhibited moderate sensitivity to AMG510 with inhibitory rate between 20% and... WebJan 14, 2016 · Mutations that increase exchange attenuated the effect of ARS853 on KRAS G12C-GTP, whereas Y32S caused a small augmentation of its effect (Fig. 3, G and H, and fig. S6, ... In H2122 and Calu-1 cells, the effect of ARS853 was potentiated by concurrent inhibition of EGFR . Inhibition of EGFR also enhanced the induction of caspase activity by ... palava cardigan
Invasive mucinous adenocarcinoma of the lung - Xu
WebExpression Public 22Q4 Copy Number Public 22Q4 Hotspot Mutations Damaging Mutations Mutation Fusion Translocation Protein Array Methylation (1kb upstream TSS) … WebJun 6, 1997 · Inhibition of Ras by the farnesyltransferase inhibitor BZA-5B inhibited prostaglandin synthesis in H2122 cells by decreasing expression of both cPLA2 and COX-2. Finally, inhibitors of eicosanoid synthesis blocked anchorage-independent growth of NSCLC lines exhibiting Ki-Ras mutations. WebAug 1, 2024 · Acquisition of secondary mutations of the target gene (on-target mechanisms), activation of bypass and accessory pathway (off-targeted mechanisms), … うしごろ 新宿三丁目 誕生日