WebSep 11, 2024 · A short and efficient total synthesis of the C 2-symmetric (−)-cylindrocyclophane F is presented, using a cross olefin metathesis dimerization strategy for construction of the [7,7]-paracyclophane macrocycle.The synthesis of the dimerization building block includes a Pd-catalyzed sp 3-sp 2 Negishi cross coupling of a sterically … WebCylindrocyclophane F C36H56O4 - PubChem compound Summary Cylindrocyclophane F Cite Download Contents 1 Structures 2 Names and Identifiers 3 Chemical and Physical …
Assembly line termination in cylindrocyclophane biosynthesis: …
Cylindrocyclophanes are a class of cyclophane, a group of aromatic hydrocarbons composed of two benzene rings attached in a unique structure. Cylindrocyclophanes were the first cyclophanes found in nature, isolated from a species of cyanobacteria, and have proven to be an interesting … See more Before the cylindrocyclophanes, the cyclophanes had all been produced synthetically. However, when a culture of the cyanobacteria Cylindrospermum lichenforme was being evaluated for antitumor activity, … See more Cylindrocyclophanes are all [7,7] paracyclophanes, differing only in the functional groups present on C-1, C-14, C-29, and C-33. There are currently 16 cylindrocyclophanes that have been identified: cylindrocyclophanes A - F, A4 - A1, C4 - C1, F4, … See more When cylindrocyclophane A was discovered, it was during an evaluation of the cyanobacteria Cylindrospermum lichenforme for antitumor activity. It was shown that … See more Since the cylindrocyclophanes have such a unique structure and exciting biological possibilities due to their cytotoxicity, there have been numerous efforts to create them synthetically in the laboratory. One of the first attempts was the total synthesis of cylindrocyclophane … See more WebDec 2, 2024 · The cyanobacterial enzyme CylK assembles the cylindrocyclophane natural products by performing two unusual alkylation reactions, forming new carbon-carbon bonds between aromatic rings and secondary alkyl halide substrates. This transformation is unprecedented in biology and the structure and mechanism of CylK are unknown. red arrows plant
Cylindrofridins A–C, Linear Cylindrocyclophane-Related …
WebApr 10, 1992 · Cylindrocyclophanes A-F are moderate cytotoxins associated with strains of the terrestrial blue-green alga Cylindrospermum licheniforme. The absolute … WebRolf Müller, R. Müller, 2004, Journal of Cancer Research and Clinical Oncology. WebJul 7, 2015 · Cylindrocyclophane biosynthesis, however, is unique in possessing both a freestanding terminating enzyme and a C-terminal TE domain on the final module of its type I modular PKS assembly line (CylH). This is surprising, as termination via a type III PKS should not require a type I TE domain. kmart east burwood hours